Rejuran vs HA skin booster vs Exosome: skin injectables compared at Seoul clinics
Rejuran, HA skin boosters and exosome treatments are three injectable options at Seoul clinics, differing in ingredients, approval status and recovery; the table lists 20 Seoul clinics offering them.
Rejuran, HA skin booster and Exosome compared on the same rows, from clinic-published pages in Seoul. 20 clinics list these treatments. Checked on 2026-10-27.
10 sources Checked
- Question
- What is the actual difference between Rejuran, an HA skin booster and an exosome treatment, and which one should I pick at a Seoul clinic?
- Treatments compared
- Rejuran, HA skin booster, Exosome
Comparison
| Rejuran | HA skin booster | Exosome | |
|---|---|---|---|
| What it is | Injectable made from polynucleotides (PN) extracted from salmon DNA, sold under the brand Rejuran Healer | Injectable hyaluronic acid delivered in microdroplets across the skin, not as a volumizing filler; examples include Hyaron | Preparation of cell-derived vesicles, applied topically after microneedling or given as small injections |
| How it works | PN is proposed to form a scaffold for cell growth and, as it breaks down, to bind adenosine A2A receptors, which clinic and review sources describe as reducing inflammation and activating fibroblasts; a PMC review calls this mechanism still hypothetical | HA draws water into the dermis to hydrate skin; some non-crosslinked formulations are marketed as stimulating fibroblasts to produce collagen and elastin, a claim from manufacturer-linked sources, not independent trials | Marketed as delivering growth factors and signalling molecules that stimulate collagen production; no independent clinical evidence for this mechanism was found in the sources reviewed |
| Regulatory status | Approved by Korea's MFDS as a medical device since 2014 for wound healing and skin regeneration indications; approved by Singapore's HSA; Australia's TGA approved it in 2023; not FDA-approved for aesthetic use in the United States | Hyaluronic acid injectables are an established device/filler category in Korea and used in many clinics, but no single approval record for every skin booster brand was located in this research | No FDA-approved exosome product exists for any indication; the FDA issued a public safety notification on December 6, 2019 after serious adverse events in patients treated with unapproved exosome products in Nebraska; no independent record of MFDS approval for an exosome skin product was found |
| Sessions | A course of 3 sessions spaced 2 to 4 weeks apart for hydration and rejuvenation, with maintenance sessions about every 3 months for skin laxity, per a PMC review and clinic protocols | A starter course of 3 sessions spaced 2 to 4 weeks apart, followed by maintenance every 6 to 12 months, per clinic protocols | A course of 3 sessions spaced about 3 weeks apart, or a range of 2 to 4 treatments, per clinic protocols |
| Downtime | Redness and swelling resolve within 24 to 48 hours according to clinic sources; combining it with laser treatments can extend recovery to 3 to 4 days, per clinic sources | Minor bruising, swelling or numbness may occur and subsides within a few days in clinic accounts; clinics describe overall downtime as minimal | Mild redness or swelling that clinics describe as subsiding within 1 to 2 days |
| Flying after | No treatment-specific guidance found; general injectable aftercare guides recommend waiting about 1 week, ideally 2, before air travel because cabin pressure can worsen swelling | No treatment-specific guidance found; general injectable aftercare guides recommend waiting about 1 week, ideally 2, before air travel | No treatment-specific guidance found in the sources reviewed; general injectable precautions would apply if the exosome product is injected instead of applied topically |
| How long it lasts | Clinic sources describe longer-term skin texture benefits with the 3-month maintenance protocol for laxity, but independent data on exact duration of results was not found | One clinic source states visible improvement lasts 6 to 9 months after completing the initial course of sessions | No independent data on duration of results was found in the sources reviewed |
| Main ingredient source | Polynucleotides purified from salmon DNA, manufactured by PharmaResearch Co., Ltd. in South Korea | Sodium hyaluronate or non-crosslinked hyaluronic acid, with manufacturers varying by brand, for example DongKook Pharmaceutical for Hyaron | Vesicles reported to be derived from stem cells or other cell sources, with sourcing varying by product and not standardized across clinics |
Clinics
| Clinic | District | Rejuran on the menu | HA skin booster on the menu | Exosome on the menu | Official page | Checked on |
|---|---|---|---|---|---|---|
| BLS Clinic | Gangnam | Rejuran | blsclinic.com | 2026-10-20 | ||
| CellOn Dermatologic Clinic | Gangnam | Rejuran | Exosome | cellonclinic.com | 2026-10-20 | |
| CORE DERMATOLOGY | Gangnam | Rejuran | Skinvive | core-derma.com | 2026-10-20 | |
| Delight Dermatology Clinic | Apgujeong | Skinvive | seouldermatologyclinic.com | 2026-10-20 | ||
| Delphic Clinic | Gangnam | Rejuran | Skinvive | Exosome | delphicclinic.com | 2026-10-20 |
| DOD Dermatology Clinic | Cheongdam | Rejuran | Exosome | dodskin.com | 2026-10-20 | |
| Doje Clinic | Gangnam | Rejuran | Skinvive | Exosome | cheongdamaestheticclinic.com | 2026-10-20 |
| Dr New Cell Clinic | Gangnam | Rejuran | Exosome | drnewcell.com | 2026-10-20 | |
| Dr. DAMI Clinic | Gangnam | Rejuran | Exosome | damiclinic.com | 2026-10-20 | |
| Ever Skin Clinic | Apgujeong | Rejuran | Exosome | dermatologistsgangnam.com | 2026-10-20 | |
| Gangnam Dermatology, Planew Clinic | Seocho | Rejuran | Skinvive | Exosome | planewclinic.com | 2026-10-20 |
| Jcell Dermatology Clinic | Cheongdam | Rejuran | Skinvive | cheongdamantiagingclinic.com | 2026-10-20 | |
| Lalian Cheongdam Clinic | Gangnam | Rejuran | Exosome | lalian-clinic.com | 2026-10-20 | |
| Liftique | Seocho | Rejuran | liftique.co.kr | 2026-10-20 | ||
| Peau Reve Clinic | Gangnam | Rejuran | Exosome | cheongdamskinclinic.com | 2026-10-20 | |
| Reberry clinic myeongdong | Myeongdong | Rejuran | Exosome | myeongdongskinclinicreberry.com | 2026-10-20 | |
| Symphony Dermatology | Apgujeong | Rejuran | Exosome | symphonyskinclinic.com | 2026-10-20 | |
| The Heal | Sinsa | Rejuran | Exosome | seoulskinspecialists.com | 2026-10-20 | |
| TheWalts Clinic | Gangnam | Rejuran | Skinvive | gangnamdermatology.clinic | 2026-10-20 | |
| UMI Skin Clinic Myeongdong | Myeongdong | Rejuran | Skinvive | Exosome | myeongdongmedspa.com | 2026-10-20 |
Sources note
Rows draw on a PMC peer-reviewed review of polynucleotide mechanisms, the FDA's public safety notification on exosome products, manufacturer and distributor product listings, and clinic treatment or aftercare pages from providers outside Korea; session counts and downtime figures vary across these clinic sources and should be confirmed with the treating clinic.
Frequently asked questions
| Question | Answer |
|---|---|
| Which of the three lasts the longest? | Independent duration data is limited. One clinic source puts HA skin booster results at 6 to 9 months after a full course, while Rejuran's longer-lasting effects are described for skin laxity with ongoing maintenance sessions every 3 months, and no independent duration figures were found for exosome treatments. |
| Can these three treatments be combined in one visit? | Clinic sources describe combining Rejuran with other procedures such as laser, which can extend downtime to 3 to 4 days, but this research found no independent data on combining all three treatments together, so ask the treating clinic about its own combination protocol. |
| Is exosome treatment officially approved anywhere? | No FDA-approved exosome product exists for any use, and the FDA issued a public safety notification in December 2019 after serious adverse events linked to unapproved exosome products. No independent confirmation of an MFDS approval for an exosome skin treatment was found in this research. |
| How soon can I fly home after treatment? | No treatment-specific flying guidance was found for Rejuran, HA skin boosters or exosome treatments. General injectable aftercare guides recommend waiting about 1 week, ideally 2, before air travel because cabin pressure can worsen swelling. |
| How many clinic visits should I plan for during a trip to Seoul? | Clinic protocols describe 3 sessions for each treatment, spaced 2 to 4 weeks apart for Rejuran and HA skin boosters and about 3 weeks apart for exosome treatments; this schedule does not fit into a single short trip unless a clinic offers an accelerated plan. |
| Is the mechanism behind these treatments proven? | A peer-reviewed review describes Rejuran's proposed scaffold and receptor-binding mechanisms as still hypothetical. HA skin booster collagen-stimulation claims and exosome growth-factor claims come from manufacturer or clinic marketing pages, not independent clinical trials. |
Sources
- primary-academic PMC: review of polynucleotide (PN) injectable mechanisms and protocols · Checked
- primary-regulatory FDA: Public Safety Notification on Exosome Products · Checked
- primary-brand-record Macau Business: PharmaResearch showcases Rejuran, manufacturer and TGA approval details · Checked
- primary-brand-record Acibadem International: Rejuran and polynucleotides, what studies show · Checked
- primary-brand-record Distinct Clinic (Singapore): Rejuran Healer treatment page · Checked
- primary-brand-record Artisan Clinics: Rejuran downtime and aftercare · Checked
- primary-brand-record Harley Academy: injector's guide to filler aftercare, including flying advice · Checked
- primary-brand-record Beautetrade: Hyaron skin booster product listing, manufacturer and concentration · Checked
- primary-brand-record DermaPure: skin booster treatment overview · Checked
- primary-brand-record Jane Yoo MD: exosome therapy overview and investigational status · Checked